家鼠型流行性出血热血清T_3、T_4、TSH的测定及意义

CHANGES OF SERUM T 3、T 4、TSH IN PATIENTS WITH URBAN TYPE EPIDEMIC HEMORRHAGIC FEVER

目的探讨家鼠型流行性出血热丘脑—垂体—甲状腺轴变化的规律。资料和方法１９９３～１９９４年在家鼠型出血热流行高峰季节，检测１０８例次病人各期血清Ｔ３、Ｔ４、ＴＳＨ含量并与正常组９０例对照。结果发热期、休克期、少尿期血清Ｔ３、Ｔ４明显低于正常组，Ｐ值均＜０．０１。血清ＴＳＨ的含量在发热期与正常组无明显差异，Ｐ＞０．０５；休克期、少尿期、多尿期明显降低，Ｐ＜０．０１。结论证实了家鼠型流行性出血热下丘脑—垂体—甲状腺轴功能的损害及各期变化规律，建议对严重低Ｔ３综合征的患者应给予甲状腺素治疗。

Objective: In order to study the changes of hypothalamus-pitaitary-thyroid axis in patients with urban type epidemic hemorrhagic fever (EHF), Methods: The levels of serum T 3、T 4、TSH were measured in 180 cases of urban type EHF during each stage and compared with those of 90 cases of normal controls. Results: The serum levels of T 3、T 4 of EHF group in febrile stage, shock stage and oligouria stage was obviously lower than those of controll group (P<0.01). There was no significant difference of the serum level of TSH. between the two group in febrile stage (P<0.05), but it was obviously decreased in shock stage, oligouria stage and polyuria stage of EHF group (P<0.01). Conclusion: The study has demonstrated that the damages and changes of hypothalamus-pituitary-thyroid axis in patients with urban type EHF in each stages. It is suggested that thyroxine therapy should be given to the patients with urban type EHF concomitant with severe low T3 syndrome.