安坦和心得安治疗抗精神病药物所致静坐不能对照研究

A DOUBLE BLIND COMPARATIVE STUDY OF EFFICACY OF BENZHEXOLHYDROCHLORIDE AND PROPRANOLOL FOR TREATMENT OF AKATHISIA CAUSED BY ANTIPSYCH OTICS

目的探讨心得安对抗精神病药物引起的静坐不能的疗效。资料和方法双盲对照研究。安坦（４８例）和心得安（４２例）治疗抗精神病药物引起的静坐不能。两组病人均选用椎体外系副反应量表和副反应量表（ＴＥＳＳ）进行疗效评定。结果安坦组静坐不能均分由治疗前的３．２４±０．４３降至治疗后的０．８４±１．２６（Ｐ＜０．０１）；心得安组静坐不能均分由治疗前的３．４２±０．５６降至治疗后的０．７９±１．３２（Ｐ＜０．０１）。两组植物神经系统副反应分值治疗前是３．１３±２．５９和３．０５±２．４８（Ｐ＞０．０５）。治疗后是６．５８±２．５４和３．５４±２．４２（Ｐ＜０．０１）。结论两种药物对抗精神病药物引起的静坐不能疗效近似；在对抗精神病药物引起的植物神经系统副反应的影响方面，心得安明显优于安坦。

Objective: To explore the efficacy of propranolol for treatment of akathisia caused by antipsychotics. Methods: The author conducted a bouble-blind comparative study of benzhexolhydrochloride (48 cases) and propranolol (42 cases) to treat the patients with akathisia. In the two groups, the sompson RS and treatment emergent symptoms (TESS) were used to assess the effects of treatment. Results: The results showed that the benzhexol hyarochloride group's akathisia mean score decreased from 3.24±0.43 to 0.84±1.26 (P<0.01) and the propranolol group's means core decreased from 3.24±0.56 to 0.79±1.32 (P<0.01). While the side effects of vegetative nervous system of the two drugs were 3.13±2.59 and 3.05 and 3.05±2.48 (P>0.05), respectively betfor treatment, and after treatment, the means were 0.58±2.54 and 3.54±2.42(P<0.01) respectively. Conclusion: This results showed that the two drugs have approximate efficacy to treat akathisia. In consideration of reducing the side effect of vegetative nervous system of the drug, propranolol was better than benzherolhydrochcoride.