血管内皮生长因子在大肠癌临床病理学中的研究及意义

Clinical pathological investigation of serum vascular endothelial growth factors level in patients with colorectal carcinoma and their significance

目的通过测定大肠癌患者术前血清血管内皮生长因子(VEGF)的含量,分析大肠癌患者术前血清VEGF的含量与临床病理学的关系;探讨其是否可作为大肠癌的诊断和预后判断的一种肿瘤标志物。方法采用ELISA法测定大肠癌患者术前的血清VEGF的含量。结果对39例大肠癌患者术前分析得出结果。血清VEGF平均水平与大肠癌临床病理学的关系:Dukes A和B期(356.5±68.5pg/ml)与C和D期(602.3±128.6pg/ml)之间有显著性差异(P<0.05)。肿瘤淋巴结转移(604.1±127.7pg/ml)与无淋巴结转移(355.2±68.79pg/ml)之间有显著性差异(P<0.05)。肿瘤远处转移(776.3±72.6pg/ml)与无远处转移(434.9±108.5pg/ml)之间有显著性差异(P<0.05)。组织学分型:高-中分化27例(427.7±163.3pg/ml),中-低分化(包括未分化和黏液腺癌)12例(579.4±141.2pg/ml),两者之间有显著性差异(P<0.05)。年龄、性别无明显差异(P>0.05)。结论VEGF对大肠癌诊断、分期、预后的判断有重要的临床意义,并可作为大肠癌诊断、分期、预后判断的肿瘤标志物。

Objective To determine the serum level of vascular endothelial growth factors （VEGF） in colorectal carcinoma and the relationship between scram VEGF and clinical pathological stage in colorectal carcinoma patients before operation and study whether the serum VEGF level can be a tumor marker of diagnosis and prognosis of eoloreetal carcinoma in the diagnosis and accompanying of eoloreetal carcinoma. Methods ELISA determined the serum VEGF. Results The serum VEGF level of 39 colorectal carcinoma patients before the operation was analyzed. Patients with Dukes stage C and D disease had significantly（ P 〈 0.05） higher levels of VEGF than patients with Dukes stage A and B. Patients with lymphode metastasis had significantly （ P 〈 0.05） higher levels of VEGF than patients without lymphode metastasis. Patients with organ metastasis had significantly （ P 〈 0.05） higher levels of VEGF than patients without organ metastasis. The serum VEGF level was significantly lower in well- moderate differentiated carcinoma than in moderate- poorly differentiated one. There were no significant correlation among gender, age with serum VEGF （ P 〉0. 05）. Conclusion VEGF with important significance for diagnosis and stage and prognosis of colorectal carcinoma. VEGF can be a tumor marker for diagnosis and stage and prognosis of colorectal carcinoma.