老年人原发性食管小细胞未分化癌（附12例报告）

Primary small cell undifferentiated carcinoma of esophagus in eldery patients: report of 12 cases

目的探讨老年人原发性食管小细胞未分化癌的发病情况、临床病理特征及治疗方法。方法分析１９８７～１９９４年我院收治的１２例老年人原发性食管小细胞未分化癌，单纯手术４例，手术结合化疗２例，单纯放疗６例。结果平均生存期：手术治疗组６个月，放疗组５个月。治疗失败的主要原因是远处转移。结论单纯手术、化疗、放疗的疗效较差，综合治疗是提高该病疗效的研究方向。

Objective To find the incidence, clinical manifestations, pathologic classification and treatment of primary small cell undifferentiated carcinoma of esophagus in elderly patients. Methods Twelve elderly patients with pathologically proved primary small cell undifferentiated carcinoma of esophagus were treated from 1984 to 1994. Four patients were treated with surgery alone, 2 with surgery and chemotherapy and 6 with radiotherapy alone. Results The median survival time was as follows: 6 months for surgery alone and 5 months for radiotherapy alone. This tumor differs from ordinary esophageal squamous cell carcinoma in that failure of treatment is mainly due to distant metastasis. Local recurrence is the second frequent cause of failure. Conclusion The result of treatment was poor for surgery, chemotherapy or radiotherapy alone. The main cause of therapeutic failure is metastasis. Further study with combination of different modalities of treatment for primary small cell undifferentiated carcinoma of esophagus in eldery patients is needed.