摘要
目的:探讨侯氏黑散对兔脑缺血.再灌注模型的血液流变、血小板聚集功能、脂质过氧化物的影响。方法:体重2-3kg的纯种大耳白兔90只,随机分为假手术(Ⅰ)组、缺血-再灌注即模型(Ⅱ)组、造模后给药(Ⅲ)组,每组30只,第Ⅲ组灌服侯氏黑散悬浊液,其余两组灌服生理盐水,连续给药1周后处死,进行指标测定。结果:第Ⅲ组的指标均好于前两组。结论:侯氏黑散可使血液粘滞状态明显改善,能降低血小板聚集率,并减少血栓形成,抑制组织匀浆液中的脂质过氧化物反应,降低脂质过氧化物含量。
Objective : To expore the effect of HOUSHIHEISAN ( HSHS ) on hemorheology of ultrastruclure change of rabbit's cerebral ischemia re-perfusion, platelet aggregtlon and lipid peroxidation. Methods: 90 pure flap-eared rabbits (2 -3kg) were selected and randomized into sham operation group ( Ⅰ ) ultrastructure change of rabbit's cerebral ischemia re-perfusion model group (Ⅱ ), Comedeled and treatment group (Ⅲ ), 30 rabbits in each group. The Ⅲ group were intragastriced administration with HOUSHIHEISAN, another 2 groups with NS everyday. The rabbits were sacrificad one week later and the chose targets were tested. Results and Conclu- sions: HOUSHIHEISAN was better than other two groups in reduce blood viscosity, decreased platelet aggregation, antithrombotic, in- hibitory reaction of lipid peroxidation in tissue homogenate and depress content of lipid peroxidation.
出处
《四川中医》
北大核心
2007年第1期20-21,共2页
Journal of Sichuan of Traditional Chinese Medicine