电针及经皮电刺激治疗糖尿病神经病变的实验研究

Effect of Electro-acupuncture and Transcutaneous Electric Nerve Stimulation on Experimental Diabetes and its Neuropathy

本文用腹腔注射链脲佐菌素（50mg／kg）诱发大鼠实验性糖尿病，48小时后血糖升高（11．1－33．3mmol／L），出现多饮、多食和多尿现象。随机分为三组，分别给以电针（EA）和经皮电刺激（TENS）治疗，取穴双侧肾俞和足三里，每次20分，每周三次，共五周；DM组未给治疗，另设ND组。到六周末治疗组血糖下降，和DM组相比，EA组差异显著（P＜0．05），三多症状也有明显改善；但TENS组没有显著差异。在四周和六周末，DM组运动神经传导速度较正常动物明显减慢（P＜0．05），而EA组和TENS组分别于四周和六周时恢复正常，与DM组比较差异显著（P＜0．05）。DM组和TENS组在造模后基础痛阈一度出现降低（痛敏），而EA组痛阈不但不降反而升高，与DM组和TENS组相比，差异显著（P＜0．05）。本实验肯定了电针对实验性糖尿病的治疗作用，为推广针灸治疗糖尿病及其神经病变提供了实验依据。

In this paper, the experimental diabetic rats induced by streptozotocin (STZ, i. p. 50 mg/kg)were divided into three groups, electro-acupuncture (EA group, n = 8), transcutaneous electric nervestimulation (TENS group, n = 8), at bilateral Shenshu and Zusanli points for 20 minutes once every 2- 3 days for five weeks, and without any treatment (DM group, n = 6) respectively. As compared withthe DM group, the increased plasma glucose levels was lowered significantly in EA group (P< 0. 05)and slightly in TENS group(P >0. 05) by the end of the sixth week. And the symtoms of polyphagia,polydipsia and polyuria were attenuated in EA group. The motor nerve conduction velocity slowing wasprevented or corrected after a course of four and six weeks treatment in EA and TENS group respec-tively. In the DM and TENS groups the pain threshold was lowered at 6 - 20 days after injection ofSTZ, but elevated in EA group, their differences were of significance (P< 0. 05). In general, the effi-ciency of EA treatment on experimental diabetes and its neuropathy was better than that of TENStherapy.