比索洛尔治疗原发性高血压82例

Bisoprolol in treating essential hypertension in 82 patients

目的：确定比索洛尔是否是治疗高血压病的好药。方法：应用比索洛尔（５～２０ｍｇ，ｐｏ，ｑｄ）治疗８２例（男性４６例，女性３６例；年龄４８．０±ｓ１．０ａ）原发性高血压病人。结果：治疗４ｗｋ后，平均坐位血压由治疗前２２．１０±０．２０／１４．２０±０．１０ｋＰａ降至１８．６０±０．２０／１１．６０±０．１０ｋＰａ。临床总有效率为９６％。常见不良反应为头晕８例，无须停药，心动过缓２例于停药１～２ｄ即缓解。结论：比索洛尔治疗轻、中度高血压疗效好，尤适用于伴心绞痛的病人，有心动过缓者禁用。

AIM:To assess whether or not bisoprolol is a good remedy for essential hypertenSion(EH).METHODS:Patients(M 46,F 36;age 48.0 ±s 1.0 a)were treated with bisoprrolol 5-20 mg,po,qd ×4 wk.RESULTS:After 4 wk of therapy,bfsoprolol reduced mean sitting systolic blood presure from 22.10 ±0.20 kPa to 18.6 ±0.20 kPa,sitting diastolic blood pressure from 14.20 ± 0.10 kPa to 11.60 ±0.10 kPa.The total clinical effective rate was 96%.Dizziness occurred in 8 patients.Bradycardia occurred in 2 patients,but gradually subsided after bisoprolol was discontinued for 1-2d.CONCLUSION :Bisoprolol is a satisfactory drug for treatment of mild to moderate hypertension patients,especially with angina pectoris,but is contraindicated in bradycardia patients.