多发性肌炎和皮肌炎患者医院尿路感染分析

Nosocomial urinary tract infection in patients with polymyositis and dermatomyositis: case analysis of 251 patients

目的探讨多发性肌炎(PM)和皮肌炎(DM)患者发生医院尿路感染的相关危险因素。方法回顾性分析1996年3月至2006年3月在我科住院的115例PM和136例DM患者,记录其中出现尿路感染病例的临床资料。结果所有PM和DM患者中发生医院尿路感染者共21例(8.37%),感染菌以革兰氏阴性菌为主(76.19%)。激素(泼尼松)用量≥30mg组医院尿路感染发生率明显高于激素用量<30mg组(9.62%vs2.33%,P<0.05);激素合并应用免疫抑制剂患者医院尿路感染发生率明显高于单用激素组(9.26%vs2.86%,P<0.05);留置导尿管患者医院尿路感染的发生率明显升高;另外,住院时间越长,肌酸肌酶水平越高,越易发生尿路感染。结论PM和DM患者医院尿路感染的相关危险因素为性别、住院时间、激素及免疫抑制剂的应用、是否留置导尿管、肌酸肌酶水平等。

Objective To investigate the risk factors of nosocomial urinary tract infection in patients with polymyositis （PM） and dermatomysitis （DM）. Methods A total of 251 patients treated in our department from March 1996 to March 2006 were analysed retrospectively. Results The incidence of nosocomial urinary tract infection was 8.37% in patients with PM and DM. The main pathogens were, Gram -negative bacilli （76. 19% ）. Nosocomial urinary tract infection was correlated with gender, hospital stay, adrenocorticoid dosage and combined use of adrenoeortieoid and immunosuppressive agents, use of indwelling urethral catheter and levels of ereatine kinase. Conclusion Urinary tract infection is one of the most common nosoeomial infection in patients with PM and DM. The main risk factors of nosocomial urinary tract infection in patients with PM and DM are gender, hospital stay, adrenocortieoid dosage and combined use of adrenocorticoid and immunosuppressive agents, use of indwelling urethral catheter and the levels of ereatine kiaase.