三氟甲基苯酚合成研究进展

Preparation Advances of Trifluoromethyl Phenol

邻位、间位、对位三氟甲基苯酚都是重要的医药、农药和染料中间体。介绍了合成三氟甲基苯酚的几种方法,包括过氧化氢氧化法、三氟甲基化法、电解法、重氮化水解法、醚水解法等,比较了各种方法的优缺点,并结合三氟甲基苯酚的生产现状,分析了今后的发展趋势。

The o-, m-, p-trifluoromethyl phenol were important intermediates in medicines, pesticides and dyes. Several methods for synthesis of trifluoromethyl phenol, included the oxidation of benzotrifluoride with hydrogen peroxide, the trifluoromethylate of phenol, the electrolysis, the diazotization and hydrolysis of trifluo- romethylaniline, the hydrolysis of ether and so on, were introduced and compared. Furthermore, the trend of the trifluoromethyl phenol was considered.