期刊文献+

移植物抗白血病效应及其调控

原文传递
导出
摘要 异基因造血干细胞移植(allo—HSCT)是治疗白血病的有效手段之一。白血病复发和移植物抗宿主病(GVHD)仍然是移植失败的最重要原因。allo-HSCT治愈白血病并非完全依赖移植前大剂量放、化疗,更重要的是通过移植物抗白血病(GVL)效应达到的。但GVL常伴发GVHD,如何将GVL与GVHD分离,调控GVL效应成为目前allo—HSCT研究热点之一。我们对此作一综述。
出处 《中华血液学杂志》 CAS CSCD 北大核心 2007年第2期141-144,共4页 Chinese Journal of Hematology
  • 相关文献

参考文献3

二级参考文献12

  • 1Klangsinsirikul P, Russell NH. Peripheral blood stem cell harvest from G-CSF-stimulated donors contain a skewed Th2 CD4 phenotype and a predominance of type 2 dendritic cells. Exp Hematol,2002;30:495-501
  • 2Mielocarek M, Graf L, Johnson G, et al. Prodution of interleukin10 by granulocyte colony-stimulating factor-mobilized blood products: a mechanism for monocyte-mediated suppression of T-cell proliferation. Blood, 1998; 92: 215 - 222
  • 3Arpinati M, Green CL, Heimfield S, et al. Granulocyte colonystimulating factor mobilizes T helper 2 inducing dendritic cells.Blood, 2000; 95:2484- 2490
  • 4Teshina T, Ferrara JL. Understanding the alloresponse: new approaches to graft-versus-host disease prevention. Semin Hematol,2002; 39:15 - 22
  • 5Harding FA, McArthur JG, Gross JA, et al. CD28 mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature, 1992; 356: 607 - 609
  • 6Blazar BR, Taylor PA, Linsley PS, et al. In vivo blockade of CD28/CTLA-4 B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across major histocompatability complex barrier in mice. Blood, 1994; 83:3815 -3825
  • 7Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science, 1999;283:1183 - 1186
  • 8Cortesini R, LeMaoult J, Ciubotariu R, et al. CD8 + CD28- T suppressor cells and the induction of antigen specific, antigen-presenting cell-mediated suppression of Th reactivity. Immunol Rev, 2001;182:201 - 206
  • 9Chang CC, Ciubotariu R, Manaralan JS, et al. Tolerization of dendritic cells by Ts cells: the crucial role of inhibilitory receptors ILT3 and ILT4. Nat Immunol, 2002 ;3:237 - 243
  • 10黄晓军,陈育红,韩伟,陈瑶,洪虹,陆道培.人类白细胞抗原不相合造血干细胞移植治疗白血病的临床研究[J].北京大学学报(医学版),2003,35(2):115-118. 被引量:20

共引文献30

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部