肝动脉化疗栓塞联合CT导向经皮瘤内注射无水乙醇治疗肝转移瘤

Transcatheter arterial chemoembolization combined with CT-guided percutaneous intratumor ethanol injection for liver metastases

目的探讨肝动脉化疗栓塞联合CT导向经皮瘤内注射无水乙醇治疗肝转移瘤的临床疗效。方法将48例（132个瘤灶）不能手术切除的肝转移瘤患者随机分为两组，对25例（68个瘤灶，治疗组）施行肝动脉栓塞化疗术（TACE）和CT导向经皮瘤内注射无水乙醇（PEI）治疗，对23例（64个瘤灶，对照组）施行单纯TACE。全部病例随访10-43个月并比较两组的疗效。结果治疗组和对照组的肿瘤缩小率分别为66．2％和48．4％；1、2、3年的生存率分别为92．0％，80．0％，64．0％和78．3％，65．2％，47．8％；局部复发率分别为16．0％和39．1％。两者比较均有明显差异（P〈0．05）。结论TACE联合CT导向PEI在肝转移瘤治疗中可相互协同，疗效优于单纯TACE。

Objective To study the clinical efficiency of transcatheter arterial chemoembolization （TACE） combined with CT-guided percutaneous intratumor ethanol injection（PEI） for liver metastases. Methods Forty-eight patients （132 lesions） with inoperable liver metastases were randomly divided into two groups. Twenty-five patients（68 lesions, study group） were treated with TACE and CT-guided PEI. Twenty-three patients （64 lesions, control group） were treated with single TACE. All the cases were followed up from 10 to 43 months, and the efficiency of the two groups was compared with. Results Tumor shrinking rate of study group and control group was 66.2% and 48.4%, respectively. Survival rate of 1 year, 2 years and 3 years of the two groups was 92.0% ,80.0%, 64.0% and 78.3%, 65.2%, 47.8%, respectively. Local recrudescent rate of the two groups was 16.0% and 39.1%, respectively. There was significant difference between the two groups in all above-mentioned. Conclusion TACE combined with CT-guided PEI could cooperate with each other in the treatment of liver metastases, and the efficiency of it was better than single TACE.