摘要
目的:探讨血清半胱氨酸蛋白酶抑制剂c(CystatinC)与血清肌酐(Scr)在不同时期慢性肾脏病(chronic kidney disease,CKD)患者肾功能检测中的敏感性,评价血清Cystatin C在各期CKD患者中的临床应用价值。方法:对129例不同时期CKD患者检测CystatinC,以^99mTc—DTPA清除率测得的肾小球滤过率(GFR)作为诊断评价的金指标,乳胶颗粒增强免疫透射比浊法检测血清CystatinC浓度,用全自动生化分析仪检测血清Scr。结果:与正常对照组比较,各期CKD组CystatinC值均有统计学差异,而各期CKD组Scr值与正常组比较,CKD1、CKD2期无统计学差异,CKD3~5期才有统计学差异;各期CKD组间比较显示CystatinC值均有统计学差异,而Scr值差异仅局限于CKD3~5期。并且血清CystatinC,Scr与^99mTc-DTPA清除率呈显著相关,尤其CystatinC相关性更好。结论:血清CystatinC在各期CKD中均能准确反映肾小球滤过功能,尤其能敏感提示早期肾功能损害,可成为判断肾功能损害程度的敏感指标,而且方法简便、敏感。
Objective:This study was designed to estimate the value of CystatinC compared with serum creatin,as a marker for indicating glornerular filtration function injury in patient with chronic kidney disease. Methods: Serum samples were obtained from 129 cases with various stage of chronic kidney disease, and GFR was estimated by the plasma clearance of ^99mTc - DTPA. Serum cystatin C concentration was detected using latex particle enhanced turbidimetry,serum creatinine was detected simultaneously using Automefic biochernicstry Analyzer. Results: Serum Cystatin C levels were found lower in all the CKD groups as compared to controls ( P〈 0.05 in each). But serum creatinine levels were only found significant differences in the groups from CKD3 to CKD5 compared with controls. Correlation coefficients with 99m Tc - DTPA were - 0. 862 for serum Cystatin C, - 0. 745 for serum creatinine. Conclusion:Serum Cystatin C is a more sensitive maker for indicating glomerular filtration function and can show early renal impairmentin in patient with chronic kidney disease.
出处
《中国中西医结合肾病杂志》
2007年第2期90-92,共3页
Chinese Journal of Integrated Traditional and Western Nephrology