摘要
目的：探讨血清半胱氨酸蛋白酶抑制剂c（CystatinC）与血清肌酐（Scr）在不同时期慢性肾脏病（chronic kidney disease，CKD）患者肾功能检测中的敏感性，评价血清Cystatin C在各期CKD患者中的临床应用价值。方法：对129例不同时期CKD患者检测CystatinC，以^99mTc—DTPA清除率测得的肾小球滤过率（GFR）作为诊断评价的金指标，乳胶颗粒增强免疫透射比浊法检测血清CystatinC浓度，用全自动生化分析仪检测血清Scr。结果：与正常对照组比较，各期CKD组CystatinC值均有统计学差异，而各期CKD组Scr值与正常组比较，CKD1、CKD2期无统计学差异，CKD3～5期才有统计学差异；各期CKD组间比较显示CystatinC值均有统计学差异，而Scr值差异仅局限于CKD3～5期。并且血清CystatinC，Scr与^99mTc-DTPA清除率呈显著相关，尤其CystatinC相关性更好。结论：血清CystatinC在各期CKD中均能准确反映肾小球滤过功能，尤其能敏感提示早期肾功能损害，可成为判断肾功能损害程度的敏感指标，而且方法简便、敏感。
Objective：This study was designed to estimate the value of CystatinC compared with serum creatin,as a marker for indicating glornerular filtration function injury in patient with chronic kidney disease. Methods： Serum samples were obtained from 129 cases with various stage of chronic kidney disease, and GFR was estimated by the plasma clearance of ^99mTc - DTPA. Serum cystatin C concentration was detected using latex particle enhanced turbidimetry,serum creatinine was detected simultaneously using Automefic biochernicstry Analyzer. Results： Serum Cystatin C levels were found lower in all the CKD groups as compared to controls （ P〈 0.05 in each）. But serum creatinine levels were only found significant differences in the groups from CKD3 to CKD5 compared with controls. Correlation coefficients with 99m Tc - DTPA were - 0. 862 for serum Cystatin C, - 0. 745 for serum creatinine. Conclusion：Serum Cystatin C is a more sensitive maker for indicating glomerular filtration function and can show early renal impairmentin in patient with chronic kidney disease.
出处
《中国中西医结合肾病杂志》
2007年第2期90-92,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
