39例芥子气皮肤损伤3年随访报告

3-year follow up survey of 39 patients with skin lesion caused by mustard gas

目的观察早期使用表皮细胞生长因子治疗、创面早期切痂植皮对芥子气皮肤损伤的疗效。方法39例芥子气皮肤损伤患者随访3年,对皮肤愈合情况进行评估。结果随访患者皮肤愈合良好,但遗留色素沉着,局部复发少。主诉皮肤损伤部位出现瘙痒、感觉异常较多,皮肤损伤后遗症目前尚难以预测。结论早期使用表皮细胞生长因子、创面早期切痂植皮治疗芥子气皮肤损伤对创面愈合、改善预后有明显的效果。

Objective To investigate the remote effects of epidermal growth factor （EGF） and early removal of eschar combined with skin grafting for the treatment of skin lesion produced by mustard gas. Methods A a-year follow-up survey was conducted in 39 patierlts with skin lesion produced by mustard gas. The condition of healing was observed and evaluated. Results Good epithelial healing with pigmentation was observed in all the surveyed patients, and only in a few of them showed local recurrence of wound. Itching and paresthesia in the wounded parts were the main complaints. The sequelae remained unpredictable. Conclusion The early use of epidermal growth factor and early removal of eschar followed by skin grafting for the treatment of skin lesion produced by mustard gas may achieve satisfactory therapeutic effect.