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虫媒黄病毒基因组复制的分子机制研究进展

Advances in research on the molecular mechanism of genome replication of arthropod-borne flaviviruses
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摘要 虫媒黄病毒包括多种重要的可导致人类疾病的病原体。对其基因组复制的分子机制的研究一直是此类病毒致病机制研究的重点。本文着重介绍病毒基因组末端与其复制相关的调控元件、病毒非结构蛋白及宿主蛋白在虫媒黄病毒基因组复制中的作用。 Arthropod-borne flaviviruses include many important human pathogens. The research on the pathogenesis of these viruses always focuses on the molecular mechanism of replication of genome. Advance in research on this field is discussed in this review, which lays emphasis on the role of the regulator elements in the terminal of the genome related to the replication, the nonstructural proteins of virus and the host proteins in the genome replication of the arthroped-borue flaviviruses.
作者 李晓峰 秦鄂德
机构地区 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室
出处 《军事医学科学院院刊》 CSCD 北大核心 2007年第1期69-73,共5页 Bulletin of the Academy of Military Medical Sciences
基金 国家"973"计划课题资助(2002CB513205)
关键词 黄病毒 基因组复制 基因组结构 NS蛋白 flavivirus genome replication genome structure NS proteins
分类号 R373.3 [医药卫生—病原生物学]
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军事医学科学院院刊
2007年 第1期

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