雷洛昔芬对绝经后妇女同型半胱氨酸及血脂的影响

Effects of raloxifene on homocysteine and serum lipids in postmenopausal women

目的观察雷洛昔芬(RLX)对绝经后妇女同型半胱氨酸及血脂的影响。方法采用随机、双盲、安慰剂对照研究,对62例绝经后妇女分为试验组(n=32)和安慰剂组(n=30),分别给予RLX 60 mg/d及安慰剂,共12个月。结果RLX组用药6个月前后同型半胱氨酸无明显变化,用药12个月时明显降低,与安慰剂组比较有显著性差异(P<0.05);RLX组用药12个月总胆固醇、低密度脂蛋白胆固醇显著降低(P<0.01),高密度脂蛋白胆固醇和甘油三酯则无明显变化。结论RLX可降低绝经后妇女同型半胱氨酸水平,降低血清总胆固醇、低密度脂蛋白胆固醇水平。

Objective： To observe the effects of raloxifene （RLX） on homocysteineEH（e）] and serum lipids in postmenopausal women. Method： Sixty-two postmenopausal women were randomized to receive either RLX 60 mg （n= 32） daily or placebo （n=30） daily for 12 months. H（e） and serum lipids were determined before the treatment and 12 months after the treatment. H（e） was also determined after 6-month drug administration. Results. Compared with the placebo control, the women treated with RLX showed no difference of H（e） after 6 months of treatment, but a significant decrease of H（e） was found after 12 months of treatment （P〈0.05）. Total cholesterol （TC） and lower-density lipoprotein cholesterol （LDL-C） in RLX treated women exhibited lower values than those in the placebo women （P〈0.01）. No difference was found for high-density lipoprotein cholesterol （HDL-C） or triglyceride levels between the two groups. Conclusion： RLX decreased H（e） and TC, LDL-C levels in postmenopausal women.