气管骨形成症3例报告并文献复习

Report of 3 cases of tracheopathia osteoplastica and literature review

目的:探讨气管骨形成症(tracheopath ia osteop lastica,TO)的临床特点,诊断要素,提高对TO的认识。方法:回顾性总结我院收治的经手术或经纤维支气管镜活检确诊的3例TO患者的临床资料,分析其临床特点、病理表现和诊疗依据。结果:3例TO患者均为男性,均有慢性咳嗽、咯痰,反复肺部感染的病史。纤维支气管镜检查可见气管、支气管软骨部结节样或鹅卵石样突起,活检可见粘膜下软骨和骨组织形成。结论:综合上述3个病历和文献认识到TO是一种罕见的病因不清的临床病理变化,可能与化学物质、油烟等慢性刺激及病人自身内分泌变化导致钙磷代谢异常有关。慢性不明原因的咳嗽应警惕本病的存在,纤维支气管镜检查是发现和确诊此病的主要手段。

Objective： To discuss the clinical characteristics and the diagnostic keys of the tracheopathia osteoplastica （TO） to improve the understanding of this disease. Methods .To review the clinical materials of the 3 hospitalized TO patients who were diagnosed by the thoracic surgery or the biopsy through the thoracocentesis and analyze the results of the clinical and pathologic manifestation, the basis of the diagnosis and the therapy. Results： All of the 3 patients were male with the chronic history of the cough, sputum and repeated pulmonary infection. The results of the fiberbronchoscope showed that there are some nodular or cobble process in the cartilage of the trachea and the bronchus which manifests the formation of the cartilage and the bone in the submucous membrane by the biopsy. Conclusion：TO is a kind of the clinic pathologic disease which the causes is unidentified and may be associated with the chronic stimulus of the chemical substances and the oil fog and the metabolic disorder of the calcium and the phosphorus in the patients. We should be on guard against the exist of this disease when there is the chronic cough. The examination of the fiberbronchoscope is the main method to find and diagnose this disease.