冠心病患者分泌型磷脂酶A2与冠状动脉病变积分及动脉硬化指数的相关性

Relationship of secretory type Ⅱ phospholipase A2,coronary artery score and atherogenic index in patients with coronary artery disease

目的探讨冠心病患者分泌型磷脂酶A2(sPLA2)与冠状动脉(冠脉)病变积分(CAS)及动脉硬化指数(AI)的相关性。方法冠脉造影确诊的冠心病患者173例,非冠心病患者89例做为对照组,分别以ELISA法测定其sPLA2水平;以计算机定量分析系统(QCA)分析冠脉狭窄程度并计算CAS;根据公式AI=[总胆固醇(TC)-高密度脂蛋白胆固醇(HDL-C)]/HDL-C计算AI。结果与对照组相比,冠心病患者的sPLA2明显升高(55.18±11.75u/mL比68.15±16.70u/mL,P<0.01),且sPLA2水平与CAS和AI均呈正相关(P<0.05),与HDL-C呈负相关。结论sPLA2在冠心病患者中明显增高,且与CAS呈正相关;sPLA2还与脂蛋白胆固醇分布紊乱有关,它与AI呈正相关,与HDL-C呈负相关。

Objective To study the relationship of secretory type H phospholipase A2 （sPLA2）, coronary artery score and atherogenic index in patients with coronary artery disease. Methods One hundred and seventy nine patients confirmed by angiography were enrolled in the coronary heart disease （CHD） group and another 89 non-CHD patients were enrolled in the control group. Serum levels of sPLA2 were measured by ELISA in all subjects. The severity of coronary artery lesions was analysed in terms of coronary artery score by quantitive computer system （QCA）. The atherogenic index （AI） was also evaluated in the 2 groups. Results Compared with the control group, serum level of sPLA2 was higher in the CHD group （55. 18 ± 11.75 u/mL vs 68.15 ± 16.70 u/mL, P 〈0.01 ）. Through Spearman correlation test, sPLA2 showed positive correlation with CAS and AI （ P 〈 0. 05 ）, while it was negatively correlated with HDL-C. Conclusion The level of sPLA2 is higher in CHD patients, which is positively correlated with CAS. In addition, it reflects maldistribution of lipoprotein cholesterol. The level of sPLA2 is positively correlated with AI but negatively correlated with HDL-C.