1Kuro M,Matsumura Y,Aizawa H,et al.Mutation of the mouse klotho gene leads to a syndrome resembling ageing[J].Nature,1997,390:45-51.
2Matsumura Y,Aizawa H,Shiraki-Iida T,et al.Identification of the human klotho gene and its two transcripts encoding membrane and secreted Klotho protein[J].Biochem Biophys Res Commun,1998,242:626-630.
3Ohyama Y,Kurabayashi M,Masuda H,et al.Molecular cloning of rat klotho cDNA:markedly decreased expression of klotho by acute inflammatory stress[J].Biochem Biophys Res Commun,1998,251:920-925.
4Shiraki-Iida T,Aizawa H,Matsumura Y,et al.Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein[J].FEBS Lett,1998,424:6-10.
5Saito Y,Yamagishi T,Nakamura T,et al.Klotho protein protects against endothelial dysfunction[J].Biochem Biophys Res Commun,1998,248:324-329.
6Saito Y,Nakamura T,Ohyama Y,et al.In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome[J].Biochem Biophys Res Commun,2000,276:767-772.
7Yamagishi T,Saito Y,Nakamura T,et al.Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors[J].Hypertens Res,2001,24:705-709.
8Kato Y,Arakawa E,Kinoshita S,et al.Establishment of the antiKlotho monoclonal antibodies and detection of Klotho protein in kidneys[J].Biochem Biophys Res Commun,2000,267:597-602.
9Masuda H,Chikuda H,Suga T,et al.Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice[J].Mech Ageing Dev,2005,126:1274-1283.
10Yamamoto M,Clark JD,Pastor JV,et al.Regulation of oxidative stress by the anti-aging hormone Klotho[J].J Biol Chem,2005,280:38029-38034.
2Wang H L, Xu Q, Wang Z, et al. A potential regulatory single nucleotide polymorphism in the promoter of the Klotho gene may be associated with essential hypertension in the Chinese Han population [ J ]. Clin Chim Acta, 2010, 411 (5/6) : 386 - 390.
3Ogata N, Matsumura Y, Shiraki M, et al. Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women[ J ]. Bone, 2002, 31 ( 1 ) : 37 - 42.
4Wolf I, Levanon-Cohen S, Bose S, et al. Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer[J]. Oncogene, 2008, 27(56): 7094-7105.
5Chen B, Wang X, Zhao W, et al. Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549[J]. J Exp Clin Cancer Res, 2010, 29: 99.
6Lee J, Jeong D J, Kim J, et al. The anti-aging gene KLOTHO is a no- vel target for epigenetic silencing in human cervical carcinoma[J]. Mol Cancer, 2010, 9: 109.
7Kurosu H, Yamamoto M, Clark J D , et al. Suppression of aging in mice by the hormone Klotho[J]. Science, 2005,309(5742) : 1829 - 1833.
8Kurosu H, Kuro 0 M. The Klotho gene family as a regulator of endocrine fibroblast growth factors [ J ]. Mol Cell Endocrinol, 2009, 299 (1): 72-78.
9Ammendola R, Mesuraca M, Russo T, et al. Spl DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues [ J ]. J Biol Chem, 1992, 267(25) : 17944 -17948.
10Liu H,Zhou M, Luo X, et al. Transcriptional regulation of BRD7 expression by Spl and c-Myc[J]. BMC Mol Biol, 2008, 9: 111.
