老年肺癌患者外周血细胞表面DC分子的表达与生存的关系

Study on the relationship between the expression levels of peripheral blood dendritic cell surface molecule and survival of old patients with lung cancer

目的从临床角度了解树突状细胞(DC)表面分子在外周血细胞表面的表达与老年肺癌患者生存的关系。方法收集确诊为肺癌的20例老年患者外周血和8例门诊健康查体老年人外周血,用流式细胞仪检测DC表型CD80、CD83、CD86和CD1a,随访1年,将死亡的老年患者和存活的患者分组,门诊健康查体老年人作为对照,进行统计学分析。结果除CD86外,老年死亡组与对照组比较CD80、CD83和CD1a均下降明显,其中CD1a在组间比较P<0.05,CD80、CD83在组间比较P<0.01;老年存活组与死亡组CD83和CD86比较差异有显著性(P<0.05);老年对照组和老年存活组CD1a、CD80、CD83和CD86比较差异无显著性。结论老年肺癌患者的死亡可能与DC细胞表面表型表达下降有关,在健康的和存活的老年人中发现,DC细胞表面表型有高表达,尤其是CD83的表达下降与肺癌患者死亡的关系较为密切。

Objectvie To study the relationship between the expression levels of peripheral blood dendritic eeU（DC） surface molecule and survival of old patients with lung cancer. Method Peripheral blood was eoUeeted from 20 old patients with lung cancer and the expression levels of CD80, CD83, CD86 and CD1a were examined using FCM. The dead and live lung cancer patients were divided into two groups during 1 year of follow up, and 8 healthy old people were used as a control group. Result The expression levels of CD80,CD83 and CD1a on DC surface between dead patients and control group were significantly different except CD86. The expression of CD1a, CD80, CD83 and CD86 between live patients and control group had no difference. Conclusion The dead patients with lung cancer had lower expression levels of CD80, CD83, CD1a and CD86 than live and healthy old people groups. The lower expression levels of CD83 may be associated with death of old patients with lung cancer.