乳腺癌术前化疗临床疗效与病理反应的关系

Relationship between clinical therapeutic effectiveness and pathological response to preoperative chemotherapy in breast cancer

目的了解乳腺癌术前化疗疗效与病理反应的关系。方法对52例Ⅱ-Ⅲ期女性乳癌行术前化疗的患者进行临床化疗疗效和病理反应的评定，并统计两者的符合情况。结果术前化疗的临床有效率为61．5％（32／52），病理反应率为67．3％（35／52）。两者之间符合率为59．6％（31／52），无明显相关性（P〉0．05）。Kappa值为0．12（小于0．40），两者间不一致。结论乳腺癌术前化疗临床疗效与病理反应不一致。乳腺癌术前化疗的临床疗效对临床的指导意义，如何提高病理反应率有待进一步进行探讨。

Objective To find out the relationship between clinical therapeutic effectiveness and pathological response to preoperative chemotherapy in breast cancer. Methods Clinical therapeutic effectiveness and pathological response were assessed to judge the degree of tumor reduction after preoperative chemotherapy in 52 patients with phase- Ⅱ to Ⅲbreast cancer, Statistical means was used to analyze if they were in accord with each other. Results The rate of clinical remission after preoperative chemotherapy was 61.5% （32/52） and the rate of pathological response was 67.3% （35/52）. The rate of accordance was 59.6% （31/52）. They were not correlated（P 〉0.05）. Kappa value was 0. 12 （〈0.40） and they were not consistent with each other. Conclusions Clinical response and pathological response in preoperative chemotherapy patients were not in accord with each other. It is suggested that the value of clinical therapeutic effectiveness in preoperative chemotherapy patients for guiding clinical practice and how to improve the rate of pathological response should be explored further.