诺维苯与紫杉醇联合顺铂治疗晚期非小细胞肺癌近期疗效比较

Comparison of short-term efficacy of navelbine and taxol combined with cisplatin in treatment of advanced non-small cell lung cancer

目的观察诺维苯、顺铂方案（NP）和紫杉醇、顺铂（TP）方案治疗Ⅲb-Ⅲ期非小细胞肺癌的疗效及毒副作用。方法40例晚期非小细胞肺癌患者中22例使用NP方案：诺维苯（NVB）25mg／m^2，iv，d1，d8；顺铂（DDP）30mg／m^2，d1-3，21d为一周期。18例使用TP方案，紫杉醇135mg／m^2，静滴3h，d1；DDP30mg／m^2，iv，d2—4。两组均使用2周期以上。结果NP组有效率36．4％，TP组脱发、肌肉酸痛发生率高于NP组。结论NP和TP方案治疗晚期非小细胞肺癌疗效相近，毒副作用均可耐受。

Objective To observe the efficacy and the side effect of NP （ NVB ＋ DDP） and TP（ taxol ＋ DDP） regimens in treatment of advanced or relapsed non-small cell lung cancer. Methods There were 40 cases failed in earlier treatment. Of them,22 employed NVB 25 mg/m^2 infusion on d1 and d8, DDP 30 mg/m^2 on d1 ,d2 and d3, 21 days comprised one cycle. Eighteen cases employed taxol 135 mg/m^2 infusion for 3 hours on dl and DDP 30 mg/m^2 on d2,d3 and d4, 21 days comprised one cycle. Both of the above two regimens were given for more than 2 cycles. Results In NP regimen group, the response（CR ＋ PR）rate was 36.4%. In TP regimen group,the response rate（CR ＋ PR） was 33.3%. Side effect group：The incidence of phlehitis in NP regimen group was higher than that in TP regimen group. Alopecia and myalgia in TP regimen group were more severe than those in NP regimen group. Conclusion In both of the two groups, the clinical treatment of non-small cell lung cancer is satisfactory and the side effect is tolerable.