反相乳液聚合制备阿霉素磁性抗癌毫微粒

The preparation of doxorubicin-loaded magnetic microsphere by inverse emusion polymerization

以阿霉素为模型药物,Fe3O4为磁核,乙烯吡咯烷酮(NVP)为载体,通过反相乳液聚合法制备了阿霉素磁性抗癌毫微粒,并对影响阿霉素磁性毫微粒大小及粒径分布的因素进行了考察.环境扫描电镜表明,最佳制备条件下制得的毫微粒外观光滑,大小均匀;激光光散射测定表明该产物平均粒径为500 nm,粒径分布系数0.23,呈单分散分布;红外光谱测试证明本实验所制备的毫微粒是由阿霉素、Fe3O4和聚乙烯吡咯烷酮共同组成.

Doxorubicin - loaded magnetic nanoparticles, using doxorubicin as model drug, Fe3O4 as core and vinylpyrrolidone as matix material, were prepared by inverse emulsion polymerization in this paper. And the effect factors on the size and the size distribution of doxorubicin - loaded magnetic nanoparticles were discussed. The optimal prepared doxorubicin -loaded magnetic nanoparti- cles have a smooth spherical surface with average size 500 nm and a narrow size distribution. And IR results indicated that the magnetic nanoparticles consists of doxorubicin, Fe3O4 and polyvinylpyr- rolidone.