黄瑞香茎皮的化学成分研究

Chemical constituents from stem bark of Daphne giraldii

目的研究黄瑞香Daphne giraldii茎皮的化学成分。方法采用液-液萃取和硅胶柱色谱对黄瑞香茎皮乙醇提取物中的成分进行分离纯化,利用核磁共振和质谱等方法确定化合物的结构。结果从乙醇提取物中分离得到7个化合物,核磁和质谱等光谱数据分析确定其分别为E-咖啡酸十八碳醇酯(Ⅰ)、(+)-nortrachelogenin(Ⅱ)、西瑞香素(Ⅲ)、daphneticin(Ⅳ)、7,8-二羟基香豆素(Ⅴ)、7-羟基香豆素(Ⅵ)和木犀草素(Ⅶ)。结论化合物为新化合物,化合物Ⅱ、Ⅳ和Ⅻ为首次从该植物中分离鉴定。

Objective To study the chemical constituents from the stem bark of Daphne giraldii. Methods The chemical constituents in the alcoholic extract from the stem bark of D. giraldii were isolated and purified using liquid/liquid extraction and silica gel column chromatography. The structures of the isolated compounds were determined on the basis of NMR, and mass spectra. Results Seven compounds were isolated from the alcohol extract. Their structures were identified as E-octadecyl caffeinate （ Ⅰ ）, （＋）-nortrachelogenin （ Ⅱ ）, daphnoretin （ Ⅲ ）, daphneticin （ Ⅳ ）, 7, 8-dihydroxy coumarin （ Ⅴ ）, 7-hy- droxy coumarin （Ⅵ）, and luteolin （Ⅶ） on the basis of ^1H-NMR, ^13C-NMR, and MS. Conclusion Compound Ⅰ is a new one. Compounds Ⅱ , Ⅳ, and Ⅶ are isolated from the title plant for the first time.