丙泊酚生理药代动力学模型种间类推的应用

The Inter-Species Extrapolation of Propofol PBPK Model

目的采用一个简单的类推方法,应用丙泊酚(异丙酚)生理药代动力学模型在羊、家兔和人之间进行类推。方法简化并验证文献中已经建立的异丙酚的羊的生理药代动力学模型,采用体表面积近似比的方法,从羊的参数值计算得到家兔和人的模型参数值,仿真得到异丙酚的家兔和人的血药浓度,并将所得到的仿真结果与实验结果相比较。结果仿真结果基本处于实验结果的误差范围之内。结论利用此方法进行种间类推基本合理。

OBJECTIVE To perform the extrapolation of a simplified propofol PBPK model among sheep, rabbit and man. METHODS A simple extrapolation method was proposed. The parameters of the model were extrapolated from sheep to rabbit and human with this method, and the simulated concentrations were compared with the measured. RESULTS The simulated concentrations tallied with those measured. CONCLUSION The method for extrapolation was rational.