正交投影分光光度法测定泻痢停片中TMP和SMZ的含量

Determinations of SMZ and TMP in Xieliting tablets by orthogonal projection spectrophotometry

目的:建立泻痢停片中TM P和SM Z的含量测定方法。方法:通过正交投影算法消除混合物光谱中干扰组分的光谱,直接测定泻痢停片中的TM P和SM Z的含量。结果:TM P和SM Z的平均回收率分别为99.91%和99.63%,RSD分别为0.14%和0.61%,样品测定结果与标准方法比较,经t检验(n=6,P>0.05)表明二者无显著性差异。结论:正交投影分光光度法测定泻痢停片中TM P和SM Z的含量,简便、准确、实用。

Objective： To develop a method to determine the contents of SMZ and TMP in Xieliting tablets. Method：By using orthogonal projection spectrophotometry, the interference component spectrum was removed from the spectrum of mixture and the contents of SMZ and TMP were directly determined. Results： The average recovery of SMZ and TMP were 99. 9% and 99. 6%,respectively, with RSD of 0.14% and 0.61%. Conclusion：This is a better quantitative method to determine the contents of SMZ and TMP in Xieliting tablets,and the method is simple, accurate and practical.