单肺通气中静脉预注川芎嗪的保护作用

Protective effects of intravenous tetramethylpyraze during one-lung ventilation

对食管癌手术单肺通气前静脉预注川芎嗪,观察肺组织超微结构及细胞内钙、镁含量变化。患者分两组,每组12倒,分别于单肺通气前及单肺通气90分钟取肺组织制备电镜标本。单肺通气前及单肺通气30分钟、60分钟抽中心、静脉血测红细胞内钙、镁含量。结果表明,对照组肺组织超微结构为,线粒体变形肿胀,嵴消失,出现大量空泡,观察组肺组织超微结构基本正常,且川芎嗪使细胞内液中钙含量降低,差异非常显著(P<0.01),从而减轻细胞钙负荷,说明川芎嗪对萎陷肺组织具有保护作用。

To evaluate the effects of tetramethylpyraze (TPZ) on the collapsed lung during one lung ventilation (OLV), 2.4 adult patients with esophageal cancer,ASA grade Ⅰ-Ⅱ,undergoing esopha-goesophagostomy, were randomly allocated to receiving intravenous infusion with TPZ 4mg·kg^(-1) (group T,n=12) or equivalent volume of normal saline (group C,n=12) in 5 mins before onset of OLV respectively. The ultrastracture of collapsed lungat 90th min following OLV showed that in group C mitochondia swelled, the cristae disappeared, and large vecule appeared, but in group T those remained normal. As compared with those in group C,the Ca^(2+) content in erythrocyte decreased significantly 30 and 60 mins following OLV (P<0.01). It is concluded that intravenous TPZ has protection for nonventilarive lung during OLV.