SIL-2R在恶性梗阻性黄疽及其并发SIRS中的变化和意义

Study on soluble interleukin-2 receptor in patients with malignant obstructive jaundice and complicated systemic inflammatory response syndrome

目的:探讨sIL-2R在恶性梗阻性黄疸及其并发SIRS中的变化规律及应用价值。方法:采用ELISA法检测血清sIL-2R,46例恶性梗阻性黄疸患者sIL-2R水平和健康对照组比较,并观察与黄疸持续时间、黄疸轻重程度以及是否并发SIRS时的变化规律,以及减黄手术前后sIL-2R的变化。结果:恶性梗阻性黄疸患者的sIL-2R明显高于健康对照组,并且随黄疸持续时间延长和黄疸的加重而升高,其中并发SIRS组明显高于无并发SIRS组,患者行减黄手术后,sIL-2R逐渐降低至接近健康人水平。结论:sIL-2R可以作为恶性梗阻性黄疸患者免疫功能状态、病情严重程度和预后判断的指标。

Objective：To explore the role of soluble interleukin-2 receptor（slL-2R） in patients with malignant obstructive jaundice and complicated SIRS, to evaluate the value of sIL-2R on predict in patients with malignant obstructive jaundice.Methods：The incidence of SIRS in patients with malignant obstructive jaundice was observed by using retrospective study. The concentration of plasma sIL-2R in patients with malignant obstructive jaundice was detected by using sandwiched ELISA.Results.The patients with malignant obstructive jaundice often complicated with SIRS. Compared with the control group, the average value of slL-2R of the group was significantly increased. The average of slL-2R was influenced by the degree and duration of obstructive jaundice. Conclusion.The serum slL-2R level might be considered as a new biological marker for the assessment of the prognosis, the state of cell-mediated immunity in malignant obstructive jaundice. The serum slL-2R level may be used to determine and monitor the severity of patients with malignant obstructive jaundice and complicated SIRS. The development serum slL-2R level can help us to detect SIRS so early that we can prevent MODS as early as possible.