随机尿样微量白蛋白/肌酐比值与24h尿白蛋白定量结果的对比研究

Comparative study between the ratio of microalbumin and creatinine of the random urine and the concentration of the uric albumin within 24 hours

目的:探讨随机尿样微量白蛋白/肌酐比值和24h尿白蛋白定量测定之间的关系。方法:分别采用放射免疫法、免疫比浊法和酶法检测124例2型糖尿病患者和58例健康体检者尿微量白蛋白/肌酐比值,24h尿白蛋白定量,空腹血糖和糖化血红蛋白A1c的浓度,并对数据进行相关统计学分析。结果:糖尿病组尿微量白蛋白/肌酐比值对数值为1.46±0.83,明显高于对照组0.42±0.14(P<0.01),且性别差异无统计学意义(P>0.05)。尿微量白蛋白/肌酐比值与24h尿白蛋白定量,空腹血糖,糖化血红蛋白A1c的相关系数分别为0.903,0.025,0.038。结论:随机尿样微量白蛋白/肌酐比值与24h尿白蛋白定量结果呈高度等级相关,可以快速诊断微量白蛋白尿。

Objective To explore the relationship between the ratio of microalbumin and creatinine of the random urine （U-mAlb/Cr） and the concentration of uric albumin within 24 hours （24h-U-Alb）. Methods Radioimmunoassay, the immunity transmission turbidimetric method and the enzymology method were used to detect the concentration of U-mAlb/Cr, 24h-U-Alb, FPG and HbAlc in 124 type 2 diabetes mellitus patients （DM group） and in 58 normal subjects（NC group）. The collected data were dealt with statistical analysis. Results The logarithmic value of U-mAlb/Cr between DM group（1.46±0. 83） and NC group （0.42±0. 14） had the significant difference （P〈 0.01）. There was no significant difference（P〉0.05） between men and women of diabetes group. The correlation coefficient between U-mAlb/Cr and 24h-U-Alb, free plasma glucose and glycation hemoglobin Alc was 0. 903,0. 025 and 0. 038. Conclusion There is a significant correlation between U-mAlb/Cr and 24h-U-Alb. U-mAlb/Cr can be used as a rapid method for early diagnosis of microalbumin urine.