仿生骨植入钛网管固定修复兔骨缺损

Bionic bone implantation combined with limited contracted titanium net duct on the repairment of rabbit bone defect

目的探讨MHA-bBMP仿生骨作为替代骨对有限接触式钛网管固定下兔股骨干缺损模型的修复作用。方法48只新西兰大白兔随机分组,实验组:MHA-bBMP仿生骨+钛网管;对照组:自体髂骨移植+钛网管。于股骨干中段截除10 mm,建立兔股骨干缺损模型,将MHA-bBMP仿生骨/自体髂骨植入骨缺损处加有限接触式钛网管固定修复骨缺损。观察兔一般情况,检测血碱性磷酸酶,进行X线片、病理组织、电镜等观察。结果钛网管组织相容性好,固定稳定有效,两组均修复了骨缺损。两组血碱性磷酸酶、X线片表现、病理组织、电镜检查的数据经统计分析无显著性差异。结论有限接触式钛网管对植入物和骨缺损断端起到可靠的固定作用;MHA-bBMP仿生骨与自体髂骨植入相比较,诱导成骨活性相当。

Objective To investigate the effect of MHA-bBMP implantation combined with limited contacted titanium net duct fixation on femoral shaft bone defect in rabbits. Methods A total of 48 rabbits were divided into experimental group （treated with bionic bone MHA-bBMP plus titanium net duct ） and control group（treated with iliac autograft plus titanium net duct）. The rabbit femoral shaft bone defect model was established by cutting 10mm bone fragment off. After operation, bionic bone MHA-bBMP/iliac autograft was implanted into the bone defect area and fixed with limited contacted titanium net duct. The general condition, serum alkaline phosphates, X-ray, histopathologic and electron microscopic examinations were performed. Results The fixation stability of titanium net duct in the two groups was good. The bone defect in the two groups was repaired. The phosphates, X-ray, histopathologic and electron microscopic examinations in the two groups were not significantly different. Conclusion The limited contacted titanium net duct can provide a reliable fixation effect on the graft and bone defect ends. Induction bone formation activity of MHA-bBMP is comparable to the iliac autograft.