期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

缝隙连接蛋白介导的细胞间通讯与胶质瘤自杀基因治疗 被引量：2

原文传递
导出
摘要 1967年Kevel首次在大鼠心肌细胞问和肝细胞问发现了一种构造精妙的连接方式，并将之命名为“缝隙连接”（gap junction，GJ）。中枢神经系统细胞问存在有多种特异性连接蛋白（connexin，CX）的分布和表达并与中枢神经系统多种疾病的发生、发展密切相关，如胶质细胞瘤、脑膜瘤、癫痫、脑缺血缺氧性损伤及Alzheimer病等。CX、GJ及由此构成的细胞内信号转导（gap junction intercellular communication，GJIC）通路在肿瘤自杀基因治疗“旁观者效应”（bystandereffect，BE）中发挥着极为重要的作用。GJ及GJIC的生理病理变化直接影响脑胶质瘤细胞的增殖、浸润及凋亡。
作者 苑玉清 游潮
机构地区 南充东方医院神经外科 四川大学华西医院神经外科
出处 《中华神经外科杂志》 CSCD 北大核心 2007年第2期156-157,共2页 Chinese Journal of Neurosurgery
关键词 缝隙连接蛋白 自杀基因治疗 脑胶质瘤细胞 细胞间通讯 Alzheimer 中枢神经系统 缺血缺氧性损伤 细胞内信号转导
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献23

  • 1Robe PJ, NGuyen O, Princen M, et al. Modulation of the HSV- TK/ganciclovir bystander effect by n-butyrate in glioblastoma:Correlation with gap-junction intercellular communication.International Journal of Oncology, 2004, 25 : 187-192.
  • 2Arishima H, Sato K, Kubota T. Immunohistochemical and ultra structural study of gap junction proteins connexin 26 and 43 in human arachnoid villi and meningeal tumors. J Neuropathol Exp Neurol, 2002, 61: 1048-1055.
  • 3Fonseaca CG, Gluten CK, Nicholson LF. Upregulation in astroc ytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lope epilepsy. Brain Res, 2002,929:105-116.
  • 4洪涛,汪阳,蒋丽萍,高子云,辜斌,迟海波.缝隙连接阻断剂1-庚醇对脑血管痉挛的抑制作用[J].中华神经外科杂志,2005,21(4):244-247. 被引量：18
  • 5Hanghey NJ, Mattson MP. Alzheimer's amyloid beta-peptide enhances ATP/gap junction- mediated calcium-wave propagation in astracytes. Neummolecular Med, 2003, 3: 173-180.
  • 6Mesnil M, Yamasaki H. Bystander effect in herpes simplex virusthymidine kinase/ganciclovir cancer gene therapy: role of gapjunctional intercellular communication. Cancer Research, 2000,60 : 3989-3999,
  • 7Carrio M, Mazo A, Lopez-lglesias C, et al, Rrtrovirus- mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: implications for gene therapy, Int J Cancer, 2001,94: 81-88.
  • 8Zhang W, DeMattia, Song H, et al. Communication between malignant glioma cells and vascular endothelial cells through gap junctions. J Neurosurg, 2003, 98: 846-853.
  • 9Zhang YW, Nakayama K, Nakayama K, et al, A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associatedprotein ( SKp2 ). Cancer Research,2003, 63 : 1623-1630.
  • 10Bansom B, Behar T, Nedergaard M. New roles for astrocytes (stars at last). Trends Neuroscience, 2003, 26: 520-522.

二级参考文献13

  • 1Christ GJ, Spray DC, Brink PR, et al. Gap junctions in vascular tissues. Circ Res , 1996, 79:631-646.
  • 2Gioia AE,Richard PW,Bijan B,et al. Evaluation of the efficacy of intrathecal nimodipine in canine models of chronic cerebral vasospasm. J Neuro,1985, 62:721-728.
  • 3Megyesi JF, Vollrath B, Cook DA, et al. In vivo animal models of cerebral vasospasm: a review. Neurosurgery, 2000, 46:448460.
  • 4Saex JC, Connor JA, Spray DC, et al. Hepatocyte gap junctions are permeable to the second messenger, inositol 1, 4, 5-trisphosphate,and to calcium ions. Proc. Natl. Acad. Sci. USA. 1989,86:2708-2712.
  • 5Kumar NM, Gilula NB. The gap junction communication channel.Cell, 1996,84: 381-384.
  • 6Hong T. Restricted expression of the gap junctional connexin 43 in the arterial system of the rat. J Anat , 1998 , 192(Pt4) :583-93.
  • 7Xin Li, Simard JM. Connexin 45 gap junction channels in rat cerebral vascular smooth muscle cells. Am J Physiol Heart Circ Physiol, 2001, 281:1890-1898.
  • 8Hirat GDS. Sympathetic neuroeffector transmission in arteries and arterioles. Physiol Rev, 1989,69:546-604.
  • 9Huidobro-Toro JP, Gonzalez R, Varas JA, et al. Spontaneous rhythmic contractions of human placental vessels: is it an evidence for a physiological pacemaker in blood vessel. Rev Med Chil, 2001,129:1105-1112.
  • 10Christ GJ. Modulation of 1-adrenergie contractility in isolated vascular tissues by heptanol: a functional demonstration of the potential importance of intercellular communication to vascularresponse generation. Life Sci, 1995, 56: 709-721.

共引文献18

同被引文献20

  • 1Zhang W, Josph A, DeMattia, et al. Communication between malignant glioma cells and vascular endothelial cells through gap junctions [ J ].J Neurosurg,2003,98(4) :846 - 853.
  • 2Zhang YW, Nakayama K, Nakayama K1, et al. A novel route for connexin 43 to inhibit cell proliferation : negative regulation of s-phase kinase-associatedprotein (SKp2) [ J]. CancerResearch, 2003,63 (7) : 1623 - 1630.
  • 3Carrio M,Mazo A,Lopez-Iglesias C, et al.Rrtrovirus-mediated transfer of the herpes simplex virus thymidlne kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander kining: implicatins for gene therapy[J] .Ira J Cancer,.2001,94(1) :81 - 88.
  • 4Rozental K, Giaume C, Spray DC. Gap junction in the nenous system[J]. Brain Kesearch Review,2000,32( 1):11 - 15.
  • 5Condorelli DF, Parenti R,Spinella F, et al. Cloning of a new gap junction gene(CX36) highly expressed in mammalian brain neurons [ J ]. Eur J Neurescience, 1998,10 : 1202 - 1208.
  • 6Teubner B, Odemeatt B, Guldenagel M, et al. Funtional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord nurons[ J ]. J Neuroscience, 2001,21 (4) : 1117 - 1126.
  • 7Soreceanu L, Manning TJ Jr,Sontheimer H. Reduced expression of connexin-43 and functional gap junction coupling in human gliomes[J]. Glia,2001,33(2) : 107 - 117.
  • 8Reinecke H, Minami E, Vitka JI, et al. C, ene transfer of connexin4-3 in the skeletal muscle[ J]. Human Gene Therapy.2004,15(7) :627 - 636.
  • 9Takuya F, Yutaka M, Frances M, et al. Development of a cancer-targeted tissue-speclfic promoter system [ J ]. Cancer Research, 2004,64 ( 1 ) : 363 - 369.
  • 10Renaud LT, Nichokas VW, Jay R, et al. Enhancement of the HSV-tk/ GCV bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap janetions[ J]. Human gene therapy, 1998,9(4) :2385 - 2391.

引证文献2

二级引证文献1

中华神经外科杂志
2007年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部