受卵体外受精-胚胎移植治疗结局分析

Analysis on the IVF-ET Results of Ovum Donation Recipients

目的:探讨受卵体外受精-胚胎移植(IVF-ET)治疗结局和疗效。方法:回顾分析2004年9月至2005年11月在本中心接受卵子赠送IVF-ET的患者共21周期的临床资料。赠卵组(20例)均采用长方案控制性超排卵行IVF-ET。受卵组(21例)采用激素替代治疗准备子宫内膜。赠卵者所赠卵子与受卵者丈夫精液行IVF-ET。选择同期常规IVF-ET患者55例做对照。结果:赠卵组种植率和临床妊娠率(7.3%,15.79%)明显低于受卵组(34.9%,52.38%)和同期IVF-ET组(21.19%,34.55%),P<0.05。结论:受卵IVF-ET是治疗卵巢功能不良和遗传原因不能生育健康后代妇女的有效方法;激素替代周期的种植率和临床妊娠率高于控制性超排卵周期。

Objective： To evaluate the IVF-ET results and the effects of ovum donation recipients. Methods： Retrospective clinic study of 21 ovum donation recipients IVF-ET cydes was performed from Oct.2004 to Nov.2005. The 21 recipients had received in vitro fertilization with their husbands＇ sperm and donors＇ oocytes. Hormone replacement treatment was used to prepare the recipients endometrial. Long protocol of Decapiptel was used in 20 donors undergoing IVF-ET.Another 55 cases of IVF-ET at the same time were as controls （COH）. Resullts： The implantation rate and the clinical pregnancy rate were 7.3% and 15.79% in donor group, significantly lower than that in HRT recipients group（34.9%, 52.38%） （ P〈 0.05） and the COH group （21.19%,34.55%） （ P 〈 0.05）. Conclusions： Oocytes donation is an effective treatment for women with dysfurctional ovarian function or genetic diseases. The implantation rate and the clinical pregnancy rate in ART cycle are significantly higher than that in COH.