血管紧张素原基因多态性与慢性心力衰竭的相关性研究

Association of angiotensinogen gene polymorphism with chronic heart failure.

目的探讨血管紧张素原基因(AGT)多态性与慢性心力衰竭(CHF)发病的关系。方法应用聚合酶链反应-限制性片段长度多态性技术检测2004年4月至2005年12月珠海市3家医院的111例CHF患者和110名健康对照者的AGT基因M235T多态性并进行统计学比较。结果共检测出3种AGT基因型,分别为MM型、MT型和TT型。CHF患者TT基因型频率高于对照组,在老年病例与对照组间,差异具有统计学意义(P=0.042)。与非TT型者相比,老年TT型者发生CHF的相对风险率为3.367。结论AGT基因M235T多态性与CHF的发生相关,TT基因型可能是该地区老年人群CHF发病的遗传危险因素。

Objective To investigate the relationship between angiotensinogen（AGT） gene M235T polymorphism and the onset of chronic heart failure（CHF）. Methods Polymerase chain reaction combined with restrictive fragment length polymorphism was used to detect the M235T variants of AGT gene in 111 CHF cases, accompanied with 110 healthy controls. Results Three kinds of AGT genotypes were detected,which were MM,MT and TY genotype separately. The frequencis of TT genotpye were higher in CHF cases than in healthy controls, and there was statistical significance in old aged group （ P = 0. 042）. The odds ratio （OR） with CHF of Tr genotype was 3. 367 compared with non-TT genotypes in old aged group. Conclusion The M235T polymorphism of AGT gene is associated with the occurrence of CHF in old aged group and TT genotype might be one of the genetic risk factors of CHF in such place of old aged population.