摘要
目的了解多发性硬化症(multiple sclerosis,Ms)患者EB病毒(EB virus,EBV)感染情况。方法收集26例临床确诊为MS患者的脑脊液(CSF)及26例正常对照组的CSF,应用ELISA法检测CSF中EBV特异的IgG的产生,并采用PCR技术检测MS患者CSF中EBV的DNA。结果在26例临床确诊为MS患者的CSF中发现IgG增高百分率为76.9%(20/26),EBV—DNA阳性率为94.6%(24/26)。结论MS患者CSF中普遍存在EBV感染情况。
Objective To investigate the infectious condition of epstein-barr virus(EBV) in the patients of multiple sclerosis(MS). Methods The CSF samples of 26 MS patients and 26 normal people were detected using enzyme-linked immunosorbent assay(ELISA) for EBV-IgG. EBV DNA was tested by polymerase chain reaction (PCR) in CSF of MS patlents and matched normal controls. Results The phenomena of increasing EBV-IgG and positive EBV-DNA were observed in CSF of most patients who were definitely diagnosed as MS. The increasing rate of EBV IgG was 76:93 % (20/26). Positive rate of EBV-DNA was 94.6 % (24/26). Conclusion EBV infection is comroon in CSF of MS patients.
出处
《中国基层医药》
CAS
2007年第2期191-192,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
黑龙江省教育厅科学技术研究项目(11513114)