补硒对支原体肺炎患儿的影响

Immunity and clinical observation on supplementing selenium to meocoplasma pneumonia in children

目的探讨硒对支原体肺炎患儿的免疫及疗效作用。方法2005年1月至2006年3月住院的120例支原体肺炎患儿为研究对象，随机分为三组，分为Ⅰ组（锌硒宝＋红霉素）、Ⅱ组（葡萄糖酸锌＋红霉素）、Ⅲ组（单纯红霉素）治疗，各组治疗前、治疗后4周分别测定免疫球蛋白IgG、IgA、IgM、C3、C4水平及观察临床症状改善情况。结果锌硒宝＋红霉素治疗组治疗支原体肺炎患儿治疗后IgG、IgA明显升高，病程明显缩短，差异有统计学意义（P〈0．01）。葡萄糖酸锌＋红霉素治疗组、单纯红霉素治疗组治疗前后IgM、C3、C4差异无统计学意义（P〉0．05）；临床症状消失时间差异无统计学意义（P〉0．05）。结论硒对支原体肺炎患儿的免疫力有明显提高作用，可缩短病程。

Objective To evaluate immunity and therapeutic effects of selenium for mycoplasma pneumonia. Methods 120 eases children with mycoplasma pneumonia from January 2005 to March 2006 were divided randomly into 3 groups： Ⅰ group（Xinxibao plus erymycine）, Ⅱ group（Putaotangsuanxin plus erymycine）, Ⅲ group（only erymycine）. The clinical symptoms and level of serum IgG, IgA, IgM, C3, C4 were observed before and after therapy. Results Compared with three groups, the levels of serum IgG, IgA were increased in Xiaxibao plus erymycine group ,and the present study showed the time of clinical symptoms was shorted obviously（ P 〈 0.01 ）. The levels of serum IgG, IgA, IgM,C3, C4 were not changed in Putaotangsuanxin plus erymycine group and erymycine group（P 〉 0.05）, and the clinical symptoms were not shorted obviously（P 〉 0.05）. Conclusion Immunnity is increased and period of treatment is shorted obviously in suffering mycoplasma pneumonia children who are Supplemented by selenium.