复方吲哚美辛栓直肠给药对产科手术切口的止痛作用

Analgesic effect of rectal compound indometacin suppositories on obstetric operative incision

目的：观察复方吲哚美辛栓治疗分娩术后切口痛的疗效。方法：对４５例会阴切开术和４０例剖宫产的分娩产妇，前者在产后次日直肠给复方吲哚美辛栓１枚（每枚含吲哚美辛７０ｍｇ和沙丁胺醇１．２ｍｇ），ｑｄ×３ｄ；后者在术日麻醉效果消失后给药，用法同前，共４次。对照组６７例，其中３５例是会阴切开术，在分娩次日给安乃近１片（０．５ｇ／片）ｐｏ，ｑｄ×３ｄ，３２例剖宫产，在术日麻醉效果消失后给丁丙诺啡１支（１００ｍｇ／支）ｉｍ，ｑｄ×３ｄ。结果：止痛作用达优、良的有效率，复方吲哚美辛组各为１００％和９５％，对照组各为５４％和４１％。２相关组疗效相比Ｐ皆＜０．０１。结论：复方吲哚美辛栓对产科术后镇痛的效果良好。

AIM:To observe analgesic efficacy of the compound indometacin suppositories (CIS) on incision after episiotomy and cesarean section. METHODS:The 45 women with episiotomy were put CIS 70 mg/badge,qd × 3 d into the rectum on the next day after operation,other 40 women with cesarean section were given(rectal) CIS of the same dosage when the anasthetic effect passed away after operation. Control groups,35 women with episiotomy received metamizole sodium 0.5g,po,qd × 3 d on the next day after the operation,other 32 women with cesarean section were injected im buprenorphine 100 mg qd × 3 d when the anasthetic effect vanished after operation. RESULTS:Analgesic response rate of CIS groups in episiotomy and cesarean section were higher those in the metamizole sodium group and the buprenorphine group (100% and 95% vs 54% and 41%).CONCLUSION:The compound indometacin suppostitories is a good drug for obstetric analgesia.