复方丹参对急性汞中毒家兔血浆、肾组织脂质过氧化物的清除作用

Effect of Compound Salvia miltiorrhiza on elimination of lipid peroxide in blood and kidneys of rabbits after acute mercury poisoning

目的：观察复方丹参注射液对急性汞中毒家兔血浆、肾组织脂质过氧化物（ＬＰＯ）的清除作用。方法：家兔３０只，分３组，汞中毒组和治疗组皮下注射ＨｇＣｌ２１．７ｍＬ／ｋｇ（每ｍＬ含ＨｇＣｌ２１０ｍｇ）。治疗组在注汞后３０ｍｉｎ及１０ｈ分别给予复方丹参注射液２ｍＬ／ｋｇ，ｉｖ。正常对照组及汞中毒组给予等剂量生理盐水。各组在中毒前、中毒后分别测定血浆、肾组织ＬＰＯ及血尿素氮（ＢＵＮ）。结果：急性汞中毒组血浆、肾组织ＬＰＯ及ＢＵＮ明显升高（Ｐ＜０．０１）。治疗组均明显下降（Ｐ＜０．０１）。结论：复方丹参注射液对汞中毒家兔血浆及肾组织ＬＰＯ有清除作用。

AIM:To study the effects of Compound Salvia miltiorrhiza on eliminating lipid peroxide(LPO) in blood and kidneys of rabbits after mercurialism. METHODS:Thirty rabbits were divided into 3 groups,Mercurialism was induced by HgCl2 17 mg/kg,sc,in the mercurialism and treatment groups.The treatment group received Compound Salvia miltiorrhiza 2 mL/kg,iv,30 min and 10 h after HgCl2.The normal control and mercurialism groups received saline 2mL/kg.LPO in blood and renal tissues.and the blood urea nitrogen (BUN) were measured before and after mercurialism. RESULTS:LPO in blood and renal tissues and BUN showed an increase(P<0. 01)in the mercurialism group,but remarkable decrease(P<0. 01) in the treatment group.CONCLUSION:Compound Salvia miltiorrhiza is effective for eliminating LPO in blood and kidneys of rabbits after mercurialism.