生长抑素在急性胰腺炎治疗中的作用

Effects of somatostatin in treating acute pancreatitis

目的：观察生长抑素治疗急性胰腺炎的疗效。方法：２０例急性胰腺炎病人中水肿型８例，重症型１２例。治疗中一组加用生长抑素持续静脉滴注，速度为２５０μｇ／ｈ，持续３～７ｄ。另一组按ＡＰＡＣＨＥＩ评分系统取同期内病情严重程度大致相近，而未加用生长抑素治疗（用禁食、胃肠减压、纠正酸碱平衡、抗感染、抑制胰腺分泌药物等方法治疗）的同等数量病人作对照组。结果：急性水肿型胰腺炎加用生长抑素组病人的血淀粉酶复常时间和总住院日虽均低于对照组，但无统计学意义（Ｐ＞０．０５），而重症型胰腺炎生长抑素组病人的血淀粉酶复常时间和总住院日均明显低于对照组（Ｐ＜０．０５）。结论：生长抑素对急性重症型胰腺炎有明显疗效。

AIM:To observe the effects of somatostatin in treating acute pancreatitis.METHODS:The somatostatin group including 8 patients with acute edematic pancreatitis(AEP) and 12 patients with acute severe pacreatitis (ASP) received a 3-7day infusion of somatostatin(250μg/h).The control group including 8 patients with AEP and 12 patients with ASP was treated without somatostatin. The severities were similar between the two groups according to APACHE Ⅱ scores. RESULTS:The treating outcomes of the two groups were compard.The duration of the return of serum amylase levels to normal and hospital stay of somatostatin group with ASP were less than those of the control group with ASP significantly (P<0.05).But there was no significant difference between the two groups with AEP(P>0.05).CONCLUSION:Somatostatin exerted its beneficial effects in treating ASP.