钝顶螺旋藻多糖和藻蓝蛋白对小鼠急性放射病的防护作用

THE PROTECTIVE EFFECTS OF POLYSACCHARIDE AND C-PHYCOCYANIN FROM SPIRULINA PLATENSIS ON ACUTE RADIATION INJURY IN MICE

本文报告了钝顶螺旋藻多糖（ＳＰＰ）和藻蓝蛋白（Ｃ－ＰＣ）对小鼠受致死剂量￣（６０）Ｃｏγ射线照射后３０天存活率的影响。在照射前５天每天给小鼠腹腔注射ＳＰＰ１２５ｍｇ／ｋｇ或Ｃ－ＰＣ５０ｍｇ／ｋｇ均能分别比对照组提高小鼠的存活率３３％和２８％同时观察了ＳＰＰ和Ｃ－ＰＣ对经￣（６０）Ｃｏγ射线亚致死剂量照射后小鼠血细胞生成的影响，结果显示，ＳＰＰ和Ｃ－ＰＣ可刺激照射后小鼠粒单系祖细胞和造血干细胞的形成，并增加骨髓有核细胞的数量。ＳＰＰ和Ｃ－ＰＣ还可以增加照射小鼠外周血细胞的总数。ＳＰＰ和Ｃ－ＰＣ对外周血红细胞数与血红蛋白量无显著的影响。结果提示：ＳＰＰ和Ｃ－ＰＣ可能促进￣（６０）Ｃｏγ射线照射小鼠造血功能的恢复。

unming mice were injected intra-peritoneally daily with polysac-charide(SPP)and C-phycocyanin(C-PC)from Spirulina platensis for 5 days before lethal irradiation by ￣(60)Co γ-ray.The 30-days survival rate of those mice was respectively increascd by 33% and 28% as comparcd with the control group(P<0.01).Simultaneously,the effect of SPP and C-PC on hematopoiesis of mice irradiated sublethally by ￣(60)Co γ-ray(5Gy)was studied.The results indicated that SPP and C-PC might stimulate thc for-mation of CFU-GM and CFU-S of irradiated mice and also enhance the number of bone marrow cell in irradiated mice.SPP and C-PC were likely to accelerate recovery of leukocyte of irradiated mice.