nm23-H1蛋白在鼻咽癌中的表达研究

Study on the expression of nm23-H1 protein in nasopharyngeal carcinoma

目的研究nm23-H1蛋白在鼻咽癌中的表达及临床意义。方法应用免疫组化法对30例鼻咽癌患者和22例慢性鼻咽炎患者的鼻咽部组织nm23-H1蛋白表达进行分析。结果nm23-H1蛋白在鼻咽癌组中的阳性率为(53.30%)低于慢性鼻咽炎组(90.91%,P<0.05);在鼻咽癌患者中,转移组的阳性率为(40.91%)低于非转移组(87.50%,P<0.05);nm23-H1蛋白表达未显示与患者年龄、性别相关。结论nm23-H1蛋白表达可能与鼻咽癌的发生、转移有关;nm23-H1蛋白的表达在鼻咽癌的早期诊断和预后观察有一定的参考价值。

Objective To investigate the expression and clinical significance of nm23 - H1 protein in nasopharyngeal carcinoma （NPC）. Methods Samples were collected from tissues of 30 nasopharyngeal carcinoma patients, 22 nasopharyngeal chronic pharyngitis and the expression level of nm23 - H1 protein were determined by immunohistochemistry. Results The positive rate of nm23 - H1 protein expressed in 30 NPC tissue was 53.30%, lower than that expressed in nasopharyngeal tissue of chronic pharyngitis patients （90.91%） showing significant differences （P 〈 0.05）. The positive rate of nm23 - H1 protein expressed in metastasis NPC tissue was 40.91 %, lower than that expressed in non- metastasis NPC （87.50%） also showing significant difference （P 〈 0. 05） ; nm23 - H1 protein expression in NPC tissues was not closely related to the age, gender of NPC patients. Conclusion The expression of nm23 - H1 protein is probably associated with the development and metastasis of nasopharyngeal carcinoma, and can be taken as one of the indicator of prognosis.