尘螨过敏性哮喘患者特异性抗体的检测及其临床意义

Detection of antibody and its clinical significance in asthma patients due to dust mite infection

目的探讨尘螨过敏性哮喘患者血清免疫球蛋白IgE、IgG亚类的临床意义。方法采用ELISA法检测36例尘螨过敏性哮喘患者血清免疫球蛋白值,以20名健康人群为对照。结果尘螨过敏性哮喘患者血清总IgE,特异性IgE、IgG1、IgG2、IgG3、IgG4的值依次为(688.28±79.16)IU/ml、(33.25±9.38)IU/ml、(44.06±7.31)IU/ml、(53.00±16.73)IU/ml、(28.69±8.46)IU/ml、(47.00±8.91)IU/ml,与对照相比,总IgE、特异性IgE、IgG1、IgG4增高,差异具有显著性(P<0.01)。结论尘螨过敏性哮喘患者体内除特异性IgE增高,IgG1、IgG4也增高,可能与哮喘发作有关,建议临床重视此项检查。

Objective To explore the clinical significance of serum immunoglobulin in asthma patients allergic to house dust mites. Methods A total of 36 asthma patients aUergie to house dust mite were detected for mite- specificity immunoglobulin using ELISA, and 20 normal health subjects were taken as eontrels. Results Compared with the eontrel group, the levels of total IgE, mite - specific IgE,IgG1 ,IgG2,IgG3,IgG4 were in the order of （688.28 ± 79.16） IU/ml, （33.25 ± 9.38）IU/ml, （44.06 ± 7.31） IU/ml,（73.00± 16.73）IU/ml,（28.69 ± 8.46）IU/ml and （47.00 ± 8.91）IU/ml. The levels of IgE, s- IgE, s- IgG1 and s- IgG4 were increased significantly in asthma patients （ P 〈 0.01 ）. Conclusion Besides mite - specific IgE, the levels of mite - specific IgGl and IgG4 increased in asthma patients that might be associated with asthma and thus clinical examination is indicated.