子宫内膜样癌中雌、孕激素受体表达的临床意义

The clinical significance of the expression of ER and PR in Endometrioid carcinoma

目的研究雌激素受体(ER)、孕激素受体(PR)在子宫内膜样癌组织中的表达及临床意义。方法采用免疫组织化学S-P法测定121例子宫内膜样癌组织中ER、PR的表达。结果子宫内膜样癌组织中ER、PR阳性表达率随着肿瘤的进展逐步下降。不同的手术病理分期ER、PR阳性率比较并无显著性差异(P均>0.05),而与组织学分级、肿瘤浸润肌层深度密切相关。组织学分级高分化腺癌(Ⅰ级)的ER、PR阳性率明显高于中、低分化者(Ⅱ、Ⅲ级)。子宫肌层浸润深度≤1/2者中的ER、PR阳性率高于浸润深度>1/2者。结论雌、孕激素受体的异常表达可能在子宫内膜样癌的发生、发展过程中起着重要作用,对子宫内膜样癌的预后和指导治疗有着重要意义。

Objective It is to investigate the clinical significance of the expression of estrogen receptor（ER） and progesterone receptor （PR） in Endometrioid carcinoma. Methods The expression of ER, PR in 121 cases of Endometrioid carcinoma was detected with the S- P immunohistochemical method. Results Along with tumor＇s histological progression, the positive rates of ER and PR in the Endometrioid carcinoma were degraded gradually. The positive rates of ER and PR were significantly related with histological grade and myometrial invasion depth, but not related with clinicopathologic stages （ P〉 0.05）. The positive expression rates of ER and PR were higher in G1 grade （well differentiated） Endometrioid carcinoma than in G2 grade （medium differentiated） or in G3 grade （poorly differentiated）. The expression rates of ER and PR were significantly higher in case with myometrial invasion depth≤1/2 than in cases with myometrial invasion ） 1/2. Conclusion The anomaly expression of ER and PR possible has important effectiveness Along with tumor＇s histological progression, it has important clinical significance to evaluate prognosis and guide iatreusis.