中国汉族人群MTHFR基因多态性与脑卒中易感性关系的Meta分析

Meta analysis on relationship between MTHFR gene polymorphism and susceptibility of stroke in Chinese Han population

目的综合评价亚甲基四氢叶酸还原酶(MTHFR)基因多态性与脑卒中的关系。方法利用Meta分析方法对17篇关于MTHFR基因多态性与脑卒中的关系的研究文献进行综合定量分析。结果共有17篇符合条件的文献纳入分析,Meta分析表明,在以CC基因型为参照,携带TT、CT基因型的个体发生脑卒中的危险性的OR值分别为2.26、1.56;按脑卒中临床类型分层分析发现,携带TT、CT基因型的个体发生缺血性与出血性脑卒中的OR值分别为2.54、1.68、2.26、1.44;携带至少一个T等位基因的个体发生脑卒中、缺血性、出血性脑卒中的危险性的OR值分别为1.80、1.84、1.71。结论MTHFR基因多态性与我国人群脑卒中的易感性密切相关。

Objective To evaluate the relationship between MTHFR gene polymorphism and susceptibility of stroke among Chinese Han population. Methods A meta-analysis of 17 epidemiological studies on MTHFR gene polymorphism and risk factors of stroke was performed. Results A total of 17 papers were selected based on the criteria. Meta-analysis results showed that the pooled OR values of stroke with TT and CT genotype were 2.26 and 1.56, respectively. Stratified by the category of stroke, the pooled OR values of ischemic stroke and hemorrhagic stroke with TT and CT genotype were 2.54, 1.68, 2.26 and 1.44, respectively. OR values of stroke and ischemic stroke and hemorrhagic stroke for subjects with at least one T allele were 1.80, 1.84 and 1.71, respectively. Conclusions MTHFR gene polymorphism is significantly associated with susceptibility of stroke in Chinese Han population.