慢性阻塞性肺病与阿尔茨海默病的病例对照研究

A case-control study on COPD and Alzheimer's Disease in elderly military male

目的探讨老年人阿尔茨海默病（AD）与慢性阻塞性肺病（COPD）的关系。方法采用病例对照研究。选择确诊的77例军队AD病人为病例组，在同一医院住院治疗的离退休老干部中按照年龄段分层抽样（按1：2比例）选取154例非痴呆对照。调查方式为电话访谈。结果单因素分析结果显示病例组社会活动情况明显少于对照组，体育锻炼情况、负性生活事件、既往COPD病史、既往癌症病史、痴呆家族史在两组间有显著性差异。在调整相关影响因素后，COPD病史致AD的OR值（95% CI）为2．122（1．007～4．472），负性生活事件、痴呆家族史、社会活动量减少的OR值分别为2．975（1．371～6．457），4．284（1．047～19．392），1．002（1．001～1．004）。结论COPD病史可能是AD的一个独立危险因素。

Objective To investigate the risk of Alzheimer＇s disease （AD） associated with life style, disease histories, family history of dementia and other risk factors. Methods We conducted a case-control study among the inpatients of Chinese PLA General Hospital in 2000 - 2003. Seventy-seven AD cases and 154 controls were selected and matched for age. Univariate and multivariate analyses were conducted using logistic regression model. Results All subjects are male aged from 66 to 102, In univafiate analysis, Chronic obstructive pulmonary disease （COPD）, lack of social activities, physical exercises, suffering from negative life events and family history of dementia were statistically different between two groups （P 〈 0.05）, Multivariate analysis showed that after adjusting for potential confounders, COPD history, suffering from negative life events, positive family histories of dementia and less social lives increased the risk of AD, The odds ratio （ OR ） and 95% confidence interval （CI） are 2,122（ 1,007- 4.472）, 2.975（1,371-6,457）, 4,284（1.047-19.392） and 1,002（1.001-1.004）, respectively, Conclusions The study demonstrates that history of COPD might be a risk factor for AD.