急性冠状动脉综合征患者经皮冠状动脉介入对左心功能的影响

Prognostic significance of left cardiac function in acute coronary syndrome patients treated with PCI

目的探讨左心室射血分数减低的急性冠状动脉综合征患者进行经皮冠状动脉介入(PCI)治疗后左心功能的变化及临床转归。方法51例急性冠状动脉综合征患者经做超声心动图分为左心室射血分数正常(NEF)组和射血分数减低(DEF)组,后者术后7d复查超声,记录两组患者心功能指标及重要心血管事件。结果DEF组中术后心功能略有改善,左心室射血分数(LVEF)、左心室短轴缩短率(FS)差异有统计学意义;两组重要心血管事件发生率差异无统计学意义。结论左心室射血分数减低的急性冠状动脉综合征患者经PCI治疗后心功能有所改善,近中期临床预后接近左心室功能正常的患者。

[Objective] To determine the clinical outcomes of acute coronary syndrome （ACS） patients with decreased left cardiac function after percutaneous coronary intervention （PCI）. [Methods] 51 ACS patients were divided into two groups： normal left ventricular ejection fraction （NEF） group （n =25, male/female： 17/8） and decreased left ventricular ejection fraction （DEF） group （n =26, male/female： 19/7）, Incidence of major adverse cardiovascular events （MACE, including cardiac death, recurrent non-fatal myocardial infarction, recurrent angina and decreased cardiac function） was recorded. [Results] There was a positive correlation for left ventricular ejection （LVEF） and fraction shortening （FS） after PCI in DEF respectively. During 6 to 31 months follow-up, there was no significant difference between two groups in incidence of MACE （P 〉0.05）. [Conclusion] ACS patients in DEF group could obtain similar clinical outcomes as patients with normal left cardiac function after PCI and aggressive medical therapy.