摘要
Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.
Novel amphiphilic polymers, cholesterol-end-capped poly （2-methacryloyloxyethyl phosphorylcholine） （CMPC） was specially designed as the drug delivery systems. Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture. Anti-cancer drug adriamycin （ADR） was incorporated into the micelles by oil-in-water method. The release of ADR from the nanosphere continued over 7 d. The drug-loaded micelles could effectively restrain the growth of cancer cell. These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第2期394-396,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:50373036)
教育部霍英东基金优选资助项目(批准号:J20040212)资助
关键词
聚合物胶柬
细胞膜仿生
药物缓释
生物相容性
磷酸胆碱
Polymeric micelles
Biomimetic of cell membrane
Drug sustained release
Biocompatibility
Phosphorylcholine
