摘要
目的 观察卡维地洛对充血性心力衰竭患者左室功能的治疗作用。方法 将121例NYHAⅡ-Ⅲ级的充血性心力衰竭患者分成两组，均使用洋地黄、血管紧张素转换酶抑制剂、利尿剂治疗。观察68例，加用卡维地洛，剂量从2．5mg，2次／d开始，每2周剂量增加1倍，渐增加至靶剂量20mg，2次／d，共6个月，与对照组53例相比较。结果 经过6个月卡维地洛治疗，65例中（68例中3例退出），40例心功能改善I一Ⅱ级，有效率达61．54％，而对照组为37．74％。另外，LVEF及E／A运动极量时间均比对照组增加明显；心率、血压较对照组下降明显。结论 卡维地洛改善充血性心力衰竭左室功能疗效显著，明显提高了生活质量，且耐受性好。
Objective To observe the therapy effect of carvedilol on left ventricular function of congestive heart failure. Methods 121 patients of congestive heart failure NYHA Ⅱ - Ⅲ were divided into two groups. They were all cured by digitaiis ACE - Ⅰ and diuretic mixture. 68 patients who added carvedilol were observed. Their dosage began from 2.5 mg bid, in every two weeks it doubled until 20 mg bid for 6months altogether. They were contrasted with other 53 patients who had not do so. Results After six months of treatment by carvedilol,40 out of 65 patients＇（ except3 out of 68） NYHA were improved to Ⅰ - Ⅱ degree. The curing effect rate added to 61.54% but that of the contrasting grop only 37.74%. And the LVEF and E/A largest spot time was obviously increased than that of contrasting group. But their heart rate and blood pressure were decreased obviously than that of control group. Conclusion Crvedilol can improve the left ventricular function of congestive heart failure and improve the quality of life. And it has a good tolerance.
出处
《中原医刊》
2007年第5期19-20,共2页
Central Plains Medical Journal
