邻苯二甲酰基化κ-卡拉胶的合成及其生物活性

Preparation and the Biological Activities of Phthaloyl κ-Carrageenan

采用硫酸水解法将κ-卡拉胶降解为低分子量卡拉胶,并制成四丁基铵盐,在适宜的反应体系中与邻苯二甲酸酐反应,得到低分子量κ-卡拉胶O-邻苯二甲酰基化衍生物。借助FT-IR对其结构进行分析,并测试酰化衍生物的凝集活性及抗氧化活性.结果表明,降解后κ-卡拉胶的结构单元没有被破坏,邻苯二甲酰基被成功地引入到κ-卡拉胶的分子链上,酰化衍生物表现出显著的血细胞凝集活性.

Low-molecular-weight（LMW） κ-Carrageenan is achieved through mild sulfuric acid hydrolysis of κ-Carrageenan, and then is turned into tetrabutyl-ammonium salt（TBA）. The salt is then acylated with phthalic anhydride in the suitable system, resulting in O-phthalyl derivatives of LMW-KC. Investigation of FT-IRspectrum shows that the disaccharide repeating unit of κ-Carrageenan is not destroyed after the degradation and the phthaloylated LMW κ-Carrageenan is successfully formed when LMW κ-Carrageenan reacts with phthalic anhydride. The biological activity shows that the phthaloylated LMW κ-Carrageenan has extraordinarily agglutinative function.