细胞增殖抑制基因HSG/Mfn2

Hyperplasia Suppressor Gene HSG/Mfn2

细胞增殖抑制基因(HSG,又称线粒体融合蛋白-2,Mfn2)是我国学者陈光慧利用差异显示技术得到的一个新基因,其编码产物HSG/Mfn2可通过抑制ERK/MAPK信号转导途径使细胞周期停滞在G0/G1期,抑制细胞增殖;还可与平滑肌α肌动蛋白相互作用参与血管平滑肌细胞再分化,在血管平滑肌细胞表型调节中起重要作用。另外,HSG/Mfn2具有促进线粒体融合的功能,与线粒体形态、结构和功能有着密切关系。HSG/Mfn2对血管增殖紊乱和其他过度增殖性疾病的发病及治疗具有重要的意义。

Hyperplasia suppressor gene （HSG, re-named mitofusin-2, Mfn2） is a novel gene identified by Kuang-Hueih Chen using a differential display technique. HSG/Mfn2 antiproliferative effect is mediated by inhibition of ERK/MAPK signalling and subsequent Go/Gt cell-cycle arrest. HSG/Mfn2 is associated with smooth muscle （SM） α-actin in vascular smooth muscle cell （VSMC）, its expression is related with VSMC differentiation and plays important roles in regulation of VSMC phenotype. In addition, HSG/Mfn2 mediates mitochondrial fusion and is associated with mitochondrial size, morphology and function. HSG/Mfn2 is an important therapeutic target for treatment of vascular proliferative disorders and other hyper-proliferative diseases as well.