植物转录因子的胞间运动

Intercellular Movement of Plant Transcription Factors

植物体的组织和器官由多细胞组成,细胞之间的通信对植物体的生长发育必不可少。转录因子作为一类特殊的蛋白质分子不仅在转录水平上参与植物生长发育的调控,而且新近研究发现,转录因子的胞间运动是细胞之间通信方式之一,具有重要的功能。对转录因子胞间运动的发现过程、转录因子胞间运动的机制及其通道进行了论述。转录因子的胞间运动有基于扩散作用的非目标性转运和具有目标性的主动转运两种模式。转录因子胞间运动具有明显的组织特异性和方向性。分析了影响转录因子胞间运动的因素,讨论了转录因子胞间运动的功能以及转录因子胞间运动所参与的植物生长发育及形态建成的调控。

Plant tissues and organs consist of multiple cells. Intercellular communication is essential in determining and enforcing developmental fates in all multicellular organisms. A growing body of evidence indicates that plant transcription factors can move between cells, suggesting that the intercellular communication mediated by transcription factor movement play an important role in controlling plant developmental events. The present article focuses on the discovery, mechanism and channel of the intercellular transcription factor movement. There are at least two modes of transcription factor movement between cells through plasmodesmata, involving either nontargeted translocation by diffusion or target-regulated transport. The intercellular movement of transcription factors is position-dependent and regulated in a tissue-specific manner. Other factors affecting the intercellular movement include the sequence and structure of the protein as well as auxiliary molecules. The recent achievements and challenges in examining the intercellular movement of transcription factors and its functions are also described and discussed in this review.