Graves眼病患者T细胞亚群与自身免疫抗体相关关系的研究

Study on the relationship of T lymphocyte subsets and autoimmune antibody in patients with Graves’ ophthalmopathy

目的通过研究早期Graves眼病(GO)患者(病程<2年)的T细胞亚群与TRAb、TMA、TGA等自身免疫抗体之间的关系,探讨免疫机制在早期GO发病机制中的作用。方法(1)采用流式细胞仪检测早期Graves眼病和正常对照组各20例的T细胞亚群及CD4+/CD8+T细胞的百分含量。(2)检测早期GO患者的TRAb、TMA、TGA并与T细胞亚群、CD4+/CD8+T细胞之间的关系进行直线相关分析。结果(1)在早期GO患者中,CD4+T细胞和CD4+/CD8+T细胞比值增高(P均<0.05)。(2)早期GO组中T细胞亚群、CD4+/CD8+T细胞的百分含量与TRAb、TMA、TGA之间无显著相关关系(P均>0.05)。结论在早期GO患者中,①存在着T细胞亚群的失衡,这在Graves眼病的发病机制中起了重要作用;②其T细胞亚群改变与甲状腺自身免疫抗体及其他自身免疫抗体之间无显著相关关系。

Objective To study the relationship between T lymphocyte subsets and autoimmune antibody such as TRAb,TMA,TGA in early patients with Graves bphthalmopathy （GO）（ course 〈 2 years）in order to explore the role of immunologic mechanism in the early GO patients. Method （ 1 ）T cell subsets were assayed by flow cytometry in patients with early GO and normal subjects（ n =20）. There was an imbalanee ofT cell subsets during the pathogenesis of early GO. （2） TRAb/TMA/TGA and T cell subsets and CD4^＋/CD8^＋T cell were assayed in earty GO patients. Results （1） The quantity of CD4^＋T cell and the ratio of CD4^＋/CD8^＋T cell increased （P〈0.05） in the pathogenesis of early GO. （2） There were no relationship between the T cell subsets CD4^＋/CD8^＋T cell and TRAb/TMA/TGA （ P 〉 0.05 ）. Conclusion The Thl -type CD4^＋T cell-mediated immunity might play a predominant role in the pathogenesis of early GO. There were no relationship between the T cell subsets and the thyroid autoimmune antibody and the other~ autoimmune antibody.